ANA patterns - list from fpnotebook

http://www.fpnotebook.com/rheum/lab/anstngptrn.htm

I. Rim Pattern

1. Systemic Lupus Erythematosus (Most Specific)

II. Homogenous Pattern

1. Systemic Lupus Erythematosus (Very specific)
2. Further evaluation
   1. Anti-dsDNA
   2. Anti-ssDNA
   3. Anti-Smith

III. Speckled Pattern

1. Most common, least specific
2. Disorders
   1. Systemic Lupus Erythematosus
   2. Mixed Connective Tissue Disease
   3. Scleroderma
   4. Sjogren's Syndrome
3. Further evaluation
   1. Smith Antibody (Anti-Smith)
   2. Ribonucleoprotein Antibody (Anti-RNP)
   3. Scl-70 kD kinetochore (Anti-Topoisomerase I)
   4. Anti-La (Anti-SSB)

IV. Nucleolar Pattern

1. Disorders
   1. Scleroderma
   2. CREST syndrome
2. Further evaluation
   1. Scl-70 kD kinetochore (Anti-Topoisomerase I)
   2. PM-1

V. Diffuse Pattern

1. Non-specific pattern

VI. Centromere Pattern

1. Seen in PSS with CREST syndrome