The common antibodies detected in PNS and their associated tumors

http://www.hindawi.com/journals/mi/2013/172986/tab4/ Table 4: The common antibodies detected in PNS and their associated tumors.

Antibodies PNS Associated tumors Antibodies against intracellular antigens Anti-Hu sensory neuronopathy, LE, BSE, encephalomyelitis SCLC Anti-Yo SCD Gynecological cancer Anti-Ri Opsoclonus-myoclonus, BSE Breast cancer Anti-Ma2 BSE, LE Testis cancer, SCLC, breast cancer Anti-CRMP5 SCD, chorea, myelitis, LE, sensory neuronopathy, optic neuritis SCLC, thymoma Anti-amphiphysin  SPS, myelitis, SCD, sensory neuronopathy SCLC, breast cancer Anti-GAD-65 SPS, myelitis SCLC, breast cancer Anti-SOX-1 LEMS SCLC Antibodies against cell surface onconeural antigens Anti-VGCC SPS, LEMS SCLC Anti-VGKC complex LE SCLC, thymoma Anti-NMDA receptor LE Teratoma Anti-AMPA receptor LE SCLC, breast cancer, thymoma Anti-AQP-4 NMO spectrum disorders SCLC, breast cancer, thymoma Anti-GABA-B receptor LE SCLC Anti-CAR Retinopathy SCLC, melanoma, gynecological cancer Anti-contactin-associated protein 2 Morvan syndrome Thymoma Anti-AchR/MuSK/RyR/Titin MG Thymoma

AMPA: amino-3-hydroxyl-5-methyl-4-isoxazole-propionate; AQP-4: aquaporin 4; CAR: cancer-associated retinopathy; CRMP5: collapsin response mediator protein 5; GABA-B: gamma-aminobutyric acid B; GAD-65: glutamic acid decarboxylase 65; LE: limbic encephalitis; LEMS: Lambert-Eaton myasthenic syndrome; MG: myasthenia gravis; NMDA: N-methyl-D-aspartate; NMO: neuromyelitis optica; SCD: subacute cerebellar degeneration; SCLC: small cell lung cancer; SPS: stiff-person syndrome; VGCC: voltage-gated calcium channel; VGKC: voltage-gated potassium channel.