Saturday, August 31, 2013

The common antibodies detected in PNS and their associated tumors

http://www.hindawi.com/journals/mi/2013/172986/tab4/
Table 4: The common antibodies detected in PNS and their associated tumors.

AntibodiesPNSAssociated tumors

Antibodies against intracellular antigens
Anti-Husensory neuronopathy, LE, BSE, encephalomyelitisSCLC
Anti-YoSCDGynecological cancer
Anti-RiOpsoclonus-myoclonus, BSEBreast cancer
Anti-Ma2BSE, LETestis cancer, SCLC, breast cancer
Anti-CRMP5SCD, chorea, myelitis, LE, sensory neuronopathy, optic neuritisSCLC, thymoma
Anti-amphiphysin SPS, myelitis, SCD, sensory neuronopathySCLC, breast cancer
Anti-GAD-65SPS, myelitisSCLC, breast cancer
Anti-SOX-1LEMSSCLC

Antibodies against cell surface onconeural antigens
Anti-VGCCSPS, LEMSSCLC
Anti-VGKC complexLESCLC, thymoma
Anti-NMDA receptorLETeratoma
Anti-AMPA receptorLESCLC, breast cancer, thymoma
Anti-AQP-4NMO spectrum disordersSCLC, breast cancer, thymoma
Anti-GABA-B receptorLESCLC
Anti-CARRetinopathySCLC, melanoma, gynecological cancer
Anti-contactin-associated protein 2Morvan syndromeThymoma
Anti-AchR/MuSK/RyR/TitinMGThymoma

AMPA: amino-3-hydroxyl-5-methyl-4-isoxazole-propionate; AQP-4: aquaporin 4; CAR: cancer-associated retinopathy; CRMP5: collapsin response mediator protein 5; GABA-B: gamma-aminobutyric acid B; GAD-65: glutamic acid decarboxylase 65; LE: limbic encephalitis; LEMS: Lambert-Eaton myasthenic syndrome; MG: myasthenia gravis; NMDA: N-methyl-D-aspartate; NMO: neuromyelitis optica; SCD: subacute cerebellar degeneration; SCLC: small cell lung cancer; SPS: stiff-person syndrome; VGCC: voltage-gated calcium channel; VGKC: voltage-gated potassium channel.