Friday, July 13, 2012

Dorsal Midbrain (Parinaud) syndrome

http://en.wikipedia.org/wiki/Parinaud%27s_syndrome

Parinaud's Syndrome is a cluster of abnormalities of eye movement and pupil dysfunction, characterized by:
  1. Paralysis of upgaze: Downward gaze is usually preserved. This vertical palsy is supranuclear, so doll's head maneuver should elevate the eyes, but eventually all upward gaze mechanisms fail.
  2. Pseudo-Argyll Robertson pupils: Accomodation reflex present, with sluggish/ absent pupillary reflex
  3. Convergence-Retraction nystagmus: Attempts at upward gaze often produce this phenomenon. On fast up-gaze, the eyes pull in and the globes retract. The easiest way to bring out this reaction is to ask the patient to follow down-going stripes on an optokinetic drum.
  4. Eyelid retraction (Collier's sign)
  5. Conjugate down gaze in the primary position: "setting-sun sign".
It is also commonly associated with bilateral papilledema. It has less commonly been associated with spasm of accommodation on attempted upward gaze, pseudoabducens palsy (also known as thalamic esotropia) or slower movements of the abducting eye than the adducting eye during horizontal saccades, see-saw nystagmus and associated ocular motility deficits including skew deviation, oculomotor nerve palsy, trochlear nerve palsy and internuclear ophthalmoplegia.

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