Tuesday, November 13, 2012

Retinal Vasculitis with CNS disease

In a patient with retinal vasculitis, it is useful to know the following:
1) Type of retinal vessels involved - arterioles, venules, capillaries
2) CSF study normal or abnormal
3) MRI Brain normal, vasculitis, white matter changes, ventricular enlargement


Identification of retinal vessels involved 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855661/
Retinal vasculitis affecting predominantly the veins (phlebitis) has been described in association with Behçet's disease, tuberculosis, sarcoidosis, multiple sclerosis, pars planitis, retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease), human immunodeficiency virus infection (HIV). Retinal arteritis is more commonly seen in acute retinal necrosis, idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) and systemic vasculitides such as SLE, polyarteritis nodosa, and Wegener's granulomatosis, Churg-Strauss syndrome and cryoglobulinemia.

List of causes of retinal vasculitis (Uptodate)


Systemic disorders
Behcet's disease
Granulomatosis with polyangiitis (Wegener's)
Sarcoidosis
Relapsing polychondritis
Systemic lupus erythematosus
Giant cell arteritis
Polyarteritis nodosa
Multiple sclerosis
Whipple's disease
Crohn's disease
HLA-B27 associated conditions



Infectious disorders
Toxoplasmosis
Tuberculosis
Syphilis
Herpes simplex
Herpes zoster
Acute retinal necrosis
Cytomegalovirus
Coccidiomycosis
Hepatitis
Amoebiasis
Candidiasis
Leptospirosis
Ricketsia
Brucellosis
Lyme disease
Human immunodeficiency virus
Toxocariasis



Ocular disorders
Birdshot retinochoroidopathy
Pars planitis
Eale's disease
Retinal arteriolitis
Behcet's sine systemic disease
Sympathetic ophthalmia




Classification of retinal vasculitis by involved vessel
Disease
Primary vessel involved
Polyarteritis nodosa
Muscular arteries
Granulomatosis with polyangiitis (Wegener's); giant cell arteritis
Medium to small arteries
Systemic lupus erythematosus
Small arteries
Whipple's disease
Capillaries
Behcet's disease; sarcoidosis; multiple sclerosis
Veins
Crohn's disease; relapsing polychondritis
Arteries and veins
HLA-B27 associated conditions, such as ankylosing spondylitis
Variable or no involvement


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