Tuesday, November 13, 2012

Wilsons disease with behavioral problems and isolated midbrain lesions

Question - can patients with Wilsons disease present with isolated psychopathic (especially abnormal sexual) behavior?
Yes - see the range of behavioral manifestations in Wilsons http://neuro.psychiatryonline.org/data/Journals/NP/3960/08JNP81.PDF , http://www.ncbi.nlm.nih.gov/pubmed/7872138 , http://books.google.co.in/books?id=Ag5710EHVpAC&pg=PA23&lpg=PA23&dq=wilsons+disease+substance+abuse&source=bl&ots=63ocZTdPcm&sig=L0H9HbqTcqwIGw-NFNk6j1iklvw&hl=en&sa=X&ei=pCyiUKH4AY7trQf0m4DoBw&ved=0CE4Q6AEwBQ#v=onepage&q=wilsons%20disease%20substance%20abuse&f=false

Question - can patients with Wilsons disease have changes only in midbrain (no changes in putamen / lenticular nuclei)
Yes - see the range of MRI abnormalities in Wilsons http://www.ncbi.nlm.nih.gov/pubmed/17894614 , http://www.ncbi.nlm.nih.gov/pubmed/20437536 , http://www.ncbi.nlm.nih.gov/pubmed/16752136

Question - can patients with Wilsons disease have only abnormality of elevated 24 hour urinary copper?
Yes - see the range of biochemical abnormalities and guidelines for diagnosis of Wilsons disease http://www.uptodate.com/contents/tests-used-in-the-diagnosis-of-wilson-disease , http://guidelines.gov/content.aspx?id=13004
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